Regional Centres enable face-to-face interaction to take place between tutors and their students within the open distance learning environment. Formal tutorials and counselling are offered, as well as informal peer support and group study sessions. The regional centres are equipped with tutorial rooms, computer laboratories, audio-visual equipment, reference books, and study material in print and CD-ROM format.

Wawasan Open University operates five Regional Centres in Malaysia: the main campus in Penang; Persiaran Green Hill in Ipoh; Cheras in Kuala Lumpur; Skudai in Johor Bahru; and Kuching in Sarawak.  In addition, two Regional Support Centres have been established in Bandar Utama and Klang.